IgA Nephropathy Insights

This week's must-know community updates, latest research & events

March 19, 2025 • Estimated Reading Time: 1 minute

Introduction to Gene Therapy - out now!

We're thrilled to announce the launch of the first guide in our gene & cell therapy series.

Read it for free here:

www.allmyhealth.io/reports

Stay tuned for next week when we will launch the next report in the series.

Would you like to sponsor the next report in the series?

Enquire here

Latest Research

In a study by Tu et al. (2025), researchers developed a new way to grade the severity of intrarenal arterial lesions (IALs) in patients with IgA nephropathy (IgAN). They retrospectively analyzed patient data to see how these lesions affected the disease's progression. The team created a semi-quantitative scoring system to assess the IALs and applied it to a cohort of patients with IgAN.

They found that higher scores, indicating more severe IALs, were associated with a worse prognosis. This suggests that assessing the severity of IALs could be important for understanding how IgAN will progress in patients. The study's findings could help doctors better predict outcomes and tailor treatments for individuals with IgAN.

Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:

Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy

A Trial of HRS-5965 Tablets in Primary IgA Nephropathy

Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)

Correlation of Microbiome and Metabonomics With IgA Nephropathy

View the full list of clinical trials →

Community News

IgA Nephropathy FoundationMar 18, 2025

From a kitchen table in New Jersey to a global movement—what a journey it has been! The IgA Nephropathy Foundation was born out of necessity, fueled by a deep desire to support patients, drive research, and ensure that no one faces IgAN alone.

As we get ready to celebrate our 21st anniversary, I’m incredibly proud of how far we’ve come—from funding critical research and advocating on Capitol Hill to launching groundbreaking programs like IgAN Care and expanding our reach globally. But our work is far from over.

We invite you to read our latest feature in Seminars in Nephrology, where we reflect on our progress, the challenges ahead, and our unwavering commitment to finding a cure.

To every patient, caregiver, researcher, and supporter—this milestone is yours as much as it is ours. Thank you for being part of this journey. YOU ARE NOT ALONE ❤️ 💙

- Bonnie Schneider

IgA Nephropathy FoundationMar 17, 2025

🚨 It’s Official – SPARK CHICAGO 2025 is SOLD OUT! 🚨

As of 10:00 AM ET, all spots for SPARK have been filled—for the 4th straight year! We are incredibly grateful for this IgAN community and the promise of hope that SPARK brings to all of us.

Missed your chance to register? Don’t worry—you can still join the waitlist, and we’ll do our best to get you in!

Thank you for your unwavering support. We can’t wait to make this year’s SPARK our most impactful yet! ❤️💙

130 days away ⏰️ 🗓️

Learn More iganspark.org

IgA Nephropathy FoundationMar 13, 2025

Join Us in Recognizing World Kidney Day!

Kidney health matters to all of us. While IgA Nephropathy is one type of kidney disease, chronic kidney disease (CKD) affects approximately 850 million people worldwide. If left undetected and untreated, CKD can lead to kidney failure, severe complications, and even premature mortality. By 2040, CKD is projected to become the 5th leading cause of years of life lost, underscoring the urgent need for global awareness and action.

This World Kidney Day, let’s come together to raise awareness, promote early detection, and advocate for better kidney health for all. Learn, share, and take action—because every kidney counts!